Saturday, July 25, 2015
Thursday, July 23, 2015
I found this article to be very helpful.
What should HER2/neu breast cancer patients and survivors eat?
Up to 25 percent of breast cancers overexpress the HER2/neu gene. HER2/neu has a role in the signal transduction pathways leading to cell growth and differentiation, which accounts for the reputation of aggressiveness of this type of breast cancer. However, there are some foods and spices that have been shown to be especially potent in inhibiting HER2 positive (HER2+) breast cancer cell growth and proliferation and promoting apoptotic cell death. Some other foods have been found to amplify the effects of Herceptin, which is used to treat HER2+ breast cancer.
Apigenin, a flavone found in foods such as parsley, celery, guava berries, bell peppers and Chinese cabbage, has been found to increase HER2+ cell death, as well as enhancing the effectiveness ofTaxol and 5-FU, which are sometimes used to treat HER2+ breast cancer.
Melatonin, which is found in almonds, cherries, tomatoes, walnuts and oats, has been shown to induce apoptosis (programmed cell death) and reduce proliferation of HER2+ breast cancer cells. Note that red meat consumption has been shown to reduce circulating melatonin.
A relatively high omega-3 to omega-6 polyunsaturated fatty acid ratio in the diet is associated with reduced risk of HER2+ breast cancer. The combination of docosahexaenoic acid (DHA, found in fatty fish) and curcumin (the main active ingredient of turmeric), has been shown to be more effective in increasing programmed cell death of HER2+ breast cancer cells than either compound used separately.
Women with HER2+ breast cancer should also review the appropriate web page concerning their individual hormone receptor subtype (ER+/PR+, ER+/PR-, ER-/PR+, or ER-/PR-).
Foods that inhibit HER2/neu breast cancer growth and proliferation
The following foods and spices or their components have been found specifically to inhibit the growth or proliferation of HER2/neu overexpressing breast cancer cells and have also been found to reduce breast cancer risk in general:
Foods and supplements that promote HER2/neu breast cancer growth
The following foods and supplements have been shown to promote HER2+ breast cancer growth or increase HER2+ expression:
- Anti-oxidant vitamins
- Folic acid supplements
- Genistein supplements
- Ligusticum chuanxiong supplements
- Milk thistle or silymarin supplements
- Si-Wu-Tang supplements
- Soy protein isolate
Foods that result in higher omega-3 to omega-6 polyunsaturated fatty acid ratio
The following foods are good dietary sources of omega-3 fatty acids:
Breast cancer patients and survivors with HER2/neu-overexpressing breast cancer should eat a wide variety of the foods on our recommended food list and limit or avoid those on our avoid list in addition to emphasizing the foods and spices on the lists above.
Below are links to recent studies on this topic. For a more complete list of studies, please click onHER2+.
Selected breast cancer studiesSensitization of HER2 Positive Breast Cancer Cells to Lapatinib Using Plants-Derived IsothiocyanatesReal Time Cell Analysis of the inhibitory effect of Vitamin K2 on adhesion and proliferation of breast cancer cellsLower Breast Cancer Risk among Women following the World Cancer Research Fund and American Institute for Cancer Research Lifestyle Recommendations: EpiGEICAM Case-Control StudyNatural product sulforaphane selectively inhibits breast cancer stem cells in basal and trastuzumab resistant Her2+ breast cancerMetformin increases survival in hormone receptor-positive, Her2-positive breast cancer patients with diabetesThe role of polycomb group protein Bmi-1 and Notch4 in breast cancer stem cell inhibition by benzyl isothiocyanatePeanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1Resveratrol suppresses the proliferation of breast cancer cells by inhibiting fatty acid synthase signaling pathwayComputational analyses of curcuminoid analogs against kinase domain of HER2Improved Clinical Outcomes Associated With Vitamin D Supplementation During Adjuvant Chemotherapy In Patients With HER2+ Non-metastatic Breast CancerSynergistic effect between Ganoderma lucidum (Reishi) and lapatinib in HER2 inflammatory breast cancer cellsInduction of Caspase-dependent Apoptosis by Apigenin by Inhibiting STAT3 Signaling in HER2-overexpressing MDA-MB-453 Breast Cancer CellsPre-diagnostic smoking behaviour and poorer prognosis in a German breast cancer patient cohort - Differential effects by tumour subtype, NAT2 status, BMI and alcohol intakeScreening to Identify Commonly Used Chinese Herbs That Affect ERBB2 and ESR1 Gene Expression Using the Human Breast Cancer MCF-7 Cell LineAssessment of Ethanol Induction of Breast Cancer Metastasis: the Involvement of ErbB2 and Endoplasmic Reticulum (ER) Stress (LB833)Docosahexaenoic acid attenuates breast cancer cell metabolism and the Warburg phenotype by targeting bioenergetic functionAqueous Maté Extract Decreases the Viability Human Breast Cancer through Apoptosis and Cancer RepressionLong-term exposure to dietary sources of genistein induces estrogen-independence in the human breast cancer (MCF-7) xenograft modelCurcumin and its Analogues (PGV-0 and PGV-1) Enhance Sensitivity of Resistant MCF-7 Cells to Doxorubicin through Inhibition of HER2 and NF-kB ActivationFolic Acid Supplementation Promotes Mammary Tumor Progression in a Rat Model
Wednesday, July 22, 2015
The extraordinary new Lucas Davenport thriller from #1 New York Times–bestselling author and Pulitzer Prize–winner John Sandford.
They call them Travelers. They move from city to city, panhandling, committing no crimes—they just like to stay on the move. And now somebody is killing them.
Lucas Davenport’s adopted daughter, Letty, is home from college when she gets a phone call from a woman Traveler she’d befriended in San Francisco. The woman thinks somebody’s killing her friends, she’s afraid she knows who it is, and now her male companion has gone missing. She’s hiding out in North Dakota, and she doesn’t know what to do.
Letty tells Lucas she’s going to get her, and, though he suspects Letty’s getting played, he volunteers to go with her. When he hears the woman’s story, though, he begins to think there’s something in it. Little does he know. In the days to come, he will embark upon an odyssey through a subculture unlike any he has ever seen, a trip that will not only put the two of them in danger—but just may change the course of his life.
Saturday, July 18, 2015
BREAST CANCER: PREDICTING INDIVIDUAL RISKVolume 8, Issue 3
When a woman undergoes testing for the most common breast cancer genes, BRCA1 and BRCA2, it is usually because she wants to know if she will developbreast cancer. However, since mutations in these genes account for just a small fraction of all breast cancers, a negative test result doesn't mean she is in the clear. Likewise, testing positive doesn't presage a future tumor.
While it's true that certain specific genetic alterations could result in a 65 percent chance of developing breast cancer during one's lifetime, other alterations could be absolutely meaningless. With such a wide range of possible outcomes, the decision of whether or not to endure a prophylactic mastectomy can seem more like gambling than medicine.
But the innovative research of geneticist Fergus J. Couch, Ph.D., of Mayo Clinic in Rochester, Minn., who is combining family history data with laboratory techniques, is giving women the genetic information they need to make crucial personal health decisions.
A telling lineage
Dr. Couch, who cut his teeth as a postdoctoral fellow in the laboratory of geneticist Francis S. Collins, M.D., Ph.D., now director of the National Institutes of Health, is widely regarded as one of the international leaders in the genomics of breast cancer. In the early 1990s, Dr. Couch was involved in the initial characterization of the BRCA1 gene and helped discover the full-length BRCA2 gene. In 1997, he came to Mayo Clinic and continues to study these two genes, with renewed emphasis on the clinical implications of his findings.
Today, Dr. Couch leads a number of international collaborations to identify and catalogue the remaining genetic risk factors for breast cancer.
"You can imagine this information will be useful for developing risk models in the future," Dr. Couch explains, "because it is all about risk and individualization of risk. Rather than giving a woman some number that really just represents the average risk of disease, we want to be able to give her a risk that takes into account her specific environmental and genetic influences."
As Dr. Couch explains it, two women with the same high-risk mutation in a breast cancer gene — and thus the same 65 percent lifetime risk of breast cancer — could, in fact, have very different outcomes. Depending on how the other 20,000-odd genes in her genome might be acting in the background, one woman may develop breast cancer at an earlier age, and the other might not ever get it.
Eager to identify the genetic factors that modify the effects of the BRCA1 and BRCA2 genes, Dr. Couch teamed up with colleagues from around the world to form the Consortium of Investigators of Modifiers of BRCA1/2. This international team is using genomewide scans to identify genetic variants (single-gene polymorphisms) that could explain the great variability in risk between individuals.
So far, the consortium has tested DNA from 17,000 BRCA1 mutation carriers and 9,000 BRCA2 mutation carriers. For his part, Dr. Couch has already uncovered a number of modifiers that can take that average risk of 65 percent up to as high as 90 percent or down to as low as 30 percent.
"If you find people at super-high risk, they may very quickly decide to do prophylactic surgery, but if you find people at a lower risk, they may decide to delay or even forgo that mastectomy," Dr. Couch says. "So it has real clinical implications. Now we have to improve on this model so that it can be brought to the clinic to help women understand what their risk is and to make more-informed clinical decisions."
Seeking other causes
Through another international consortium, Dr. Couch is looking for the causes of sporadic breast cancer, when the disease appears seemingly at random and with no apparent genetic cause. The endeavor, called the Breast Cancer Association Consortium, has studied 100,000 sporadic cases, pinpointing 60 different regions of the genome that increase the risk of breast cancer.
As part of this project, Dr. Couch and epidemiologistCeline M. Vachon, Ph.D., also of Mayo Clinic in Rochester, Minn., are investigating risk factors for a specific subset of the disease known as triple-negative breast cancer. Although it makes up only 12 percent of all cases, triple-negative breast cancer is the most aggressive form of the disease and is difficult to treat because the tumors don't contain estrogen, progesterone and HER2 receptors. By scanning the entire genome of 5,000 triple-negative breast cancer patients, the researchers have been able to identify nine new markers of the disease.
"The interesting thing about these particular markers is that we do not see some of them in the other forms of breast cancer, so they may be unique to triple negative breast cancers," Dr. Couch says. "Remember, we are looking at mutations present in every cell in the body, not just the tumor. So at the very basic blood level there are factors that specifically predispose you to triple-negative breast cancer."
Coming full circle
Dr. Couch's quest to uncover the causes of many different forms of breast cancer has led him from the laboratory to the clinic and back again. His work at the bench has demonstrated that BRCA2, a known DNA repair gene, has an important role in cell division.
This novel function may help to explain why BRCA2 mutant breast tumors have high levels of genome instability. For instance, many breast cancer tumors either lose or gain big chunks of the genome, including a section of chromosome 17. Dr. Couch began to wonder if having extra copies of the genes within that region might actually be driving cancer.
His laboratory genetically engineered a series of mice to contain more than the usual dose of these genes in the mammary gland. Two of these juiced-up genes caused breast cancer in the mutant mice. When researchers compared their results to tumors from breast cancer patients, they found that the activity levels of these same two genes were highest in patients with poor outcomes. Dr. Couch now believes they have found two novel breast cancer genes, and he is back in the lab trying to understand how they are involved in cancer metastasis and progression.
"It was interesting to take what we had found in human tumors, put it into mice, find the specific gene responsible, and then we take it back around and show that it does make sense with regard to the outcome and progression of patients," Dr. Couch says. "We just have to figure out how it all works, and how it fits into the overall picture of a woman's risk. That is all in the future."
Breaking breast cancer's code
For 1 out of every 10 women tested for breast cancer gene mutations, the findings are even more uncertain. Ten percent of test results reveal a change in the BRCA1 or BRCA2 genes, yet whether or not that genetic alteration will lead to cancer is not known.
In 2009, Dr. Couch launched another international consortium to determine which of these genetic changes, called variants of uncertain significance, are background genetic noise and which are harbingers of disease. This new consortium is combining family history studies with molecular biology to calculate the odds that a particular mutation is causing disease.
Today, this consortium includes 100 scientists and physician-researchers from 17 countries. It meets twice a year to share family information, functional data and new ideas for cataloguing the more than 2,000 variants of uncertain significance identified so far.
"What Dr. Couch has done is bring together people globally to accomplish things that no one institution could do on its own," says James N. Ingle, M.D., the Betty J. Foust, M.D., and Parents’ Professor at Mayo Clinic, and director of Mayo Clinic's Breast Cancer SPORE, which funds the new consortium. "One of the important parts of his work is the translation of this information so that no matter where in the world a woman is being seen, she knows whether her mutation is a bad result or a neutral result. The whole point of this is to bring advantage to the patient, who, in turn, could avoid these substantial prophylactic surgeries and also perhaps worry a little bit less about cancer."
BRCA1 and BRCA2 are by far the most common breast cancer-predisposing genes, yet they only account for 5 to 10 percent of all breast cancers, and less than half of all familial cases. So it is not surprising that Dr. Couch is also interested in discovering other breast cancer genes and risk factors.
He is going back to families whose members have breast cancer not explained by BRCA1 and BRCA2 mutations and sequencing their genes to look for genetic changes that track with disease. The research is in collaboration with the University of Delaware and City of Hope Comprehensive Cancer Center in California, but Dr. Couch is hoping to extend it across international lines and recently met with investigators from 20 research groups from around the world.